The objective of this research is to study the location by type of activity and the specialization of the states in Mexico, with the variable occupation according to sex, with the purpose of analyzing the occupational dynamics between men and women in the years 2008 and 2018. A methodology is used of location coefficients and relative specialization that allows analyzing the development of the location of the sectors and classes, and the specialization that their entities show. In addition to the entities that contributed instead in the specialization in both sexes, were Baja California, Durango, Guanajuato, Hidalgo, Jalisco, Mexico, Puebla, San Luis Potosí, Sonora, Yucatán and Zacatecas, at the class level. And those that presented greater specialization at the sector level are Chihuahua, Mexico City, Guerrero, Nayarit, Quintana Roo, Tabasco and Veracruz. The other states presented equal specialization coefficients for both levels (sector and class). And the sectors that contributed the most to the location in the calculation with data for both genders were Manufacturing industries, agriculture and livestock, and services.