University social responsibility comprises a voluntary and comprehensive activity, developed to meet internal and external needs, creating from its actions a shared commitment in society, which alludes to a managerial perspective that is concerned with the management of institutional tasks, promoting the participation of all interest groups, in order to achieve sustainability from its missionary function. Therefore, the purpose of this article, the result of research, was to analyze social responsibility as a voluntary and comprehensive activity at the University of La Guajira. Methodologically, research is a quantitative paradigm, positivist approach, descriptive type, non- experimental, transactional field design. The population 527 subjects from the administrative and academic areas of the university under study, having a sample of 173 subjects. The information collection was made with the survey technique and a 6-item questionnaire instrument with multiple response options, previously validated by 10 experts and applied reliability through a pilot test, with the alpha cronbach formula reaching a 92% reliability. Descriptive statistics were used to analyze the information, and its results were the input to issue conclusions and recommendations. In general terms, the University of La Guajira, with its motto of academia and social projection, seeks to integrate the university community in the exercise of voluntary activity, both internal and external, of social responsibility, working as a team with all interest groups for the common good, through a synergy of activities that articulate the university and society under the dynamic management of knowledge to contribute to social sustainability.